It's 1978, and Ave Maria Mulligan is the thirty-five-year-old self-proclaimed spinster of Big Stone Gap, a sleepy hamlet in the Blue Ridge Mountains of Virginia. She's also the local pharmacist, the co-captain of the Rescue Squad, and the director of The Trail of the Lonesome Pine, the town's long-running Outdoor Drama. Ave Maria is content with her life of doing errands and negotiating small details-until she discovers a skeleton in her family's formerly tidy closet that completely unravels her quiet, conventional life. Suddenly, she finds herself juggling two marriage proposals, conducting a no-holds-barred family feud, planning a life-changing journey to the Old Country, and helping her best friend, the high-school band director, design a halftime show to dazzle Elizabeth Taylor, the violet-eyed Hollywood movie star who's coming through town on a campaign stump with her husband, senatorial candidate John Warner.

Filled with big-time eccentrics and small-town shenanigans, Big Stone Gap is a jewel box of original characters, including sexpot Bookmobile librarian Iva Lou Wade; Fleeta Mullins, the chain-smoking pharmacy cashier with a penchant for professional wrestling; the dashing visionary Theodore Tipton; Elmo Gaspar, the snake-handling preacher; Jack MacChesney, a coal-mining bachelor looking for true love; and Pearl Grimes, a shy mountain girl on the verge of a miraculous transformation.

Comic and compassionate, Big Stone Gap is is the story of a woman who thinks life has passed her by, only to learn that the best is yet to come.